RESUMO
The polymorphisms of the complement components C2, C3, C4 and BF have been studied in a sample of 166 unrelated individuals from Northern Greece. The C3*F and BF*F allele frequencies of Greeks are within the range of frequencies reported from Europe. A single individual with a rare heterozygote variant C2C/C2A was found in Greeks. This C2*A allele was found for the first time in European Caucasoids. For the C4 system six different alleles were found at both C4A and C4B loci. There were a low frequency of the null alleles at the C4A locus and a relatively high incidence of gene duplications in this system.
Assuntos
Proteínas do Sistema Complemento/genética , Frequência do Gene , Polimorfismo Genético , Complemento C2/genética , Complemento C2a , Complemento C3/genética , Complemento C4a/genética , Complemento C4b/genética , Fator D do Complemento/genética , Grécia , Humanos , Família MultigênicaRESUMO
PAGIF was used to investigate the distribution of Gc and Tf subtypes in a Greek population sample. The gene frequencies were compared to those reported for other European populations.
Assuntos
Transferrina/genética , Proteína de Ligação a Vitamina D/genética , Eletroforese em Gel de Poliacrilamida , Frequência do Gene , Grécia , Humanos , FenótipoRESUMO
Gene frequency data on 16 protein and blood group loci for the inhabitants of 9 Mediterranean countries were collected from the literature. The frequency of most of these genes was associated with longitude. The genetic distances between the same populations were also determined. The smallest genetic distances were found among the north Mediterranean countries, whereas the highest values were observed between the Algerians and the inhabitants of the other countries.
Assuntos
Frequência do Gene , Ásia Ocidental , Antígenos de Grupos Sanguíneos/genética , Proteínas Sanguíneas/genética , Enzimas/genética , Europa (Continente) , HumanosRESUMO
The placental alkaline phosphatase (Aph) polymorphism was studied in Northern Greece. A new rare placental Aph variant was described.
Assuntos
Fosfatase Alcalina/genética , Feminino , Frequência do Gene , Grécia , Humanos , Isoenzimas/genética , Placenta/enzimologia , Polimorfismo Genético , GravidezRESUMO
Gene frequency data of several genetic markers in 9 Mediterranean countries as well as in the 3 major human races were collected from the literature. Using these data the genetic distances between the inhabitants of the 9 countries and the 3 human races were determined. Algerians are closer to Negroids, while the other Mediterraneans are closer to Caucasoids.
Assuntos
Marcadores Genéticos , Grupos Raciais , Argélia , Bulgária , Egito , Feminino , França , Frequência do Gene , Genética Médica , Grécia , Humanos , Israel , Itália , Líbia , Masculino , Espanha , TurquiaRESUMO
Gene frequencies for 12 genetic loci have been studied in the district of Almopia in Northern Greece. The frequencies of the G6PD and Hb loci exhibited clinical changes from NW to SE in central Macedonia. In the whole Greek population, the mean proportion of polymorphic loci and the mean heterozygosity were 0.73 and 0.202, respectively. Several statistically significant differences between Macedonians and Bulgarians were found.
Assuntos
Genes , Polimorfismo Genético , Antígenos de Grupos Sanguíneos/genética , Proteínas Sanguíneas/genética , Bulgária , Defeitos da Visão Cromática/genética , Eritrócitos/enzimologia , Frequência do Gene , Grécia , Humanos , Feniltioureia/metabolismoRESUMO
The phenotypes and gene frequencies of eight enzyme and three protein systems were electrophoretically determined in 225 patients with affective disorders, 95 of which were suffering from schizophrenia. In five polymorphic systems studied, no significant differences were found between the gene frequencies of the total sample and the normal controls and between the schizophrenic group and either the total sample or the controls.
Assuntos
Proteínas Sanguíneas/genética , Enzimas/sangue , Polimorfismo Genético , Transtornos Psicóticos/genética , Esquizofrenia/genética , Adenilato Quinase/sangue , Adenilato Quinase/genética , Frequência do Gene , Glucosefosfato Desidrogenase/sangue , Glucosefosfato Desidrogenase/genética , Grécia , Humanos , Fenótipo , Transtornos Psicóticos/enzimologia , Esquizofrenia/enzimologiaRESUMO
A study was carried out dealing with the acid phosphatases, in larvae, pupae and adults of Drosophila auraria. The most interesting finding is that the acid phosphatases are observed in 3 different phenotypes appearing as groups of 3 bands of different mobilities in the homozygotes and giving a 5 band phenotype in the heterozygote. A hypothesis is discussed in an attempt to explain the phenotypes observed and their variation during the development of the species.
